Nick and Juliette will contemplate making a huge sacrifice in order for him to retrieve his Grimm powers in the next all-new episode of NBC's "Grimm."

A preview of the upcoming episode, "Cry Luison," reveals that Nick's Wesen enemies will discover that he is no longer a Grimm and go after him to seek revenge. As a result, he and Juliette will decide that the only way to stop the monsters is by becoming a Grimm again. However, that means that Juliette will have to transform into Adalind in order for Nick to get his powers back, reports The Hollywood Hills.

In the meantime, Bud will request Trubel's help in a matter regarding a Wesen and Nick.

According to Spoiler TV, NBC issued a press release with the official synopsis for "Cry Luison":

"Nick (David Giuntoli) and Hank (Russell Hornsby) are called to the scene of a crime where the suspect swears she was driven to madness by a very persistent talking wolf. Meanwhile, Nick and Juliette (Bitsie Tulloch) wonder if getting his Grimm powers back is worth giving up a normal life.

"Elsewhere, Bud (guest star Danny Bruno) hopes Trubel (guest star Jacqueline Toboni) can help take care of a Wesen-related issue, and the threats against Monroe (Silas Weir Mitchell) and Rosalee's (Bree Turner) inter-Wesen marriage heat up.

"In Austria, Adalind (Claire Coffee) continues her perilous trek in the hopes of retrieving her daughter."

In the last week's episode, "Dyin' on a Prayer," an ancient creature made of red clay called a Golem was summoned by prayer to serve as a protector, notes Dread Central. However, things quickly got out of hand when the Golem, which is a part of Jewish folklore, ends up killing a few men to protect a young boy. As a result, Nick called on Trubel to help in the case.

Season 4 Episode 5 of "Grimm," "Cry Luison," premieres on NBC on Friday, Nov. 21, at 9 p.m. ET.

Watch the trailer video below.