Deadpool is an anti-hero. Not only that, he does not care about most things but he can afford to. Why? Because he has the same healing factor as Wolverine does. Deadpool is virtually unkillable. So how do you tackle someone who can never die? By unique villains.

Deadpool did so well on its first week of production that it actually recieved positive reviews from its critics. According to Cinema Blend, "Deadpool 2" is already in the makings and should be released some time around the beginning of 2018. So far the cast is unknown, except of course Ryan Reynolds.

This is the perfect time for Marvel Fanatics to step up their game and predict the best villains that are able to take on Deadpool. Movie News Guide did an article about the best potential villains for Deadpool and admittedly they are quite good.

For starters, Taskmaster is the best choice. Taskmaster has appearead in animations before and was seen as a villain for the Avengers. However later on he became a personalized villain against Deadpool only. Taskmaster is more brains then brawns.

For instance, he has the power to imitate any individual's fighting moveset. If your opponent knows all your moves then they can certainly know how to counter them. He also is considered a genius and a master level planner/tactician.

Secondly, one can look at Madcap. Madcap, according to the comics, has nearly the same regenerative powers as Deadpool and so they both stand head to head when it comes to fighting. Since he cannot be killed as well he can foil Deadpool's plans and certainly be a nuisance.

Finally, Super Skrull is the better choice. Super Skrull comes from an alien race of species which were involved as being imposters for Marvel Heroes. Super Skrull also has this ability which allows him to combine all four powers from the Fantastic 4 and use them properly. Imagine Deadpool trying to beat that.

Surely there are other foes for Deadpool, but these three listed above are some of the best choices across the minds of many people.